Pinealon
Also known as: Pinealon
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) studied in Russian research as a brain-targeted peptide bioregulator with proposed neuroprotective and cognition-supporting effects. It is part of the Khavinson short-peptide bioregulator family.
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Mechanism of Action
Pinealon is a tripeptide hypothesized to cross cell membranes and the blood-brain barrier and to interact with DNA regulatory regions, modulating tissue-specific gene expression in neurons. Preclinical work suggests it reduces oxidative stress, limits free-radical-induced apoptosis, and supports neuronal survival under hypoxic or excitotoxic conditions. It is reported to influence expression of genes tied to antioxidant defense and neuronal differentiation. Evidence comes mainly from cell culture and rodent models.
- Half-life
- Short; estimated minutes in circulation for the free peptide
- Administration Routes
- subcutaneous, intramuscular
- Research Status
- Preclinical
Reported Benefits
- Studied for neuroprotection against oxidative and hypoxic stress
- Investigated for support of learning and memory in animal models
- Proposed antioxidant activity in neural tissue
- Explored for reducing neuronal apoptosis in preclinical work
- Part of a bioregulator class researched for brain aging
Potential Side Effects
- Limited human safety data
- Possible injection-site irritation
- Headache or altered sleep reported anecdotally
- Unknown long-term effects in humans
Common Dosing
For research use only and not medical advice: preclinical animal studies have used microgram-to-milligram exposures; no validated human dosing exists. Anecdotal research protocols cite roughly 1-10 mg per administration.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy and breastfeeding
- Known peptide hypersensitivity
- Use alongside CNS-active medications without supervision
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Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes
2011
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Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease
2021
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Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
2012
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EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease
2020