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Also known as: PE-22-28, Spadin analog
A spadin-derived peptide studied as a fast-acting antidepressant candidate that works by blocking the TREK-1 potassium channel, with reported neurogenic and neuroprotective effects.
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PE-22-28 is a shortened analog of spadin that selectively blocks the TREK-1 (two-pore-domain) potassium channel, a target implicated in depression. TREK-1 inhibition increases neuronal excitability and is reported to promote rapid antidepressant effects and hippocampal neurogenesis in preclinical models. It has also been investigated for neuroprotection in stroke models, reflecting TREK-1's broader role in the nervous system.