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Also known as: Pancragen
Pancragen is a synthetic short peptide bioregulator (Lys-Glu-Asp-Trp) studied in Russian research for supporting pancreatic function and glucose metabolism. It belongs to the Khavinson family of peptide bioregulators developed to normalize tissue-specific gene expression in aging organs.
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Pancragen is a tetrapeptide proposed to act as a peptide bioregulator that penetrates cells and binds regulatory regions of DNA, modulating tissue-specific transcription in pancreatic acinar and islet cells. Research suggests it influences expression of genes linked to insulin synthesis and carbohydrate metabolism, and may upregulate antioxidant defenses. The peptide is hypothesized to restore homeostatic gene expression patterns that decline with aging. These mechanisms are characterized primarily in cell culture and rodent models rather than controlled human trials.