Pancragen
Also known as: Pancragen
Pancragen is a synthetic short peptide bioregulator (Lys-Glu-Asp-Trp) studied in Russian research for supporting pancreatic function and glucose metabolism. It belongs to the Khavinson family of peptide bioregulators developed to normalize tissue-specific gene expression in aging organs.
Last updated
Mechanism of Action
Pancragen is a tetrapeptide proposed to act as a peptide bioregulator that penetrates cells and binds regulatory regions of DNA, modulating tissue-specific transcription in pancreatic acinar and islet cells. Research suggests it influences expression of genes linked to insulin synthesis and carbohydrate metabolism, and may upregulate antioxidant defenses. The peptide is hypothesized to restore homeostatic gene expression patterns that decline with aging. These mechanisms are characterized primarily in cell culture and rodent models rather than controlled human trials.
- Half-life
- Short; estimated minutes in circulation for free peptide
- Administration Routes
- subcutaneous, intramuscular
- Research Status
- Preclinical
Reported Benefits
- Studied for support of pancreatic exocrine and endocrine function
- Investigated for normalization of carbohydrate metabolism in aged models
- May support insulin-producing islet cell activity in preclinical studies
- Proposed antioxidant and tissue-protective effects
- Part of a peptide bioregulator class explored for healthy aging
Potential Side Effects
- Limited human safety data available
- Possible injection-site irritation with parenteral use
- Theoretical changes in blood glucose regulation
- Unknown long-term effects in humans
Common Dosing
For research use only: rodent and in vitro studies have used microgram-range exposures; no validated human dosing exists and figures below are not medical advice. Reported research protocols cite roughly 0.1-1 mg per administration in animal models.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy and breastfeeding
- Known peptide or excipient hypersensitivity
- Active pancreatic disease without clinical supervision
Epitalon
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the pineal peptide epithalamin, studied for telomerase activation, circadian regulation, and longevity in animal and limited human research.
Prostamax
Prostamax is a synthetic peptide bioregulator studied in Russian research for supporting prostate tissue function and urinary health in aging males. It belongs to the short-peptide bioregulator family popularized by Khavinson.
Cardiogen
Cardiogen is a short synthetic peptide (Ala-Glu-Asp-Arg) studied as a cardiovascular bioregulator intended to support heart and vascular tissue. It belongs to the Khavinson family of short peptide bioregulators.
Thymalin
A thymus-derived peptide preparation studied in Russian research for immune restoration and age-related immune support, often paired with Epitalon in longevity protocols.
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Prospects of using pancragen for correction of metabolic disorders in elderly people
2011
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Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus
2007
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[Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys]
2014
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Effects of pancragen on the differentiation of pancreatic cells during their ageing
2013