Loading peptide…
PeptideChat is for educational and research purposes only. Nothing on this site constitutes medical advice. Peptides are sold as research chemicals only and are not intended for human use. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. PeptideChat is an independent educational resource — not a pharmacy, compounding, or 503A/503B outsourcing facility — and does not sell products or provide medical advice.
Also known as: Orexin B, Hypocretin-2
A 28-amino-acid hypothalamic neuropeptide that, alongside Orexin A, regulates arousal, wakefulness and feeding. It shows relative selectivity for the OX2R receptor subtype.
Sign in to rate this peptide.
Orexin B (hypocretin-2) is cleaved from the same prepro-orexin precursor as Orexin A and signals through orexin receptors, with a marked preference for OX2R over OX1R. Activation of OX2R on histaminergic and monoaminergic neurons promotes cortical arousal and stabilizes the waking state. The peptide also contributes to appetite regulation and autonomic activation. Its OX2R selectivity makes it a useful probe for dissecting the wake-promoting versus reward-related roles of the orexin system.