N-Acetyl PT-141
Also known as: N-Acetyl PT-141
N-Acetyl PT-141 is an N-terminally acetylated analog of the melanocortin peptide PT-141 (bremelanotide) studied for effects on sexual arousal and libido. The acetylation is intended to improve stability while retaining melanocortin receptor activity.
Last updated
Mechanism of Action
N-Acetyl PT-141 is a melanocortin receptor agonist derived from alpha-MSH and the PT-141/bremelanotide scaffold, acting primarily at central MC4R (with activity at MC3R). MC4R activation in hypothalamic circuits modulates dopaminergic signaling that drives sexual desire and arousal, producing effects centrally rather than through the vascular pathway used by PDE5 inhibitors. N-terminal acetylation caps the peptide to slow aminopeptidase degradation, potentially extending stability and exposure. The parent compound bremelanotide is FDA-approved for hypoactive sexual desire disorder, but this acetylated analog itself is a research chemical.
- Half-life
- Estimated several hours; not formally established for this analog
- Administration Routes
- subcutaneous
- Research Status
- Research Chemical
Reported Benefits
- Studied for enhancement of sexual desire and arousal in both sexes
- Acts through central melanocortin pathways rather than vascular ones
- May work independently of the nitric-oxide/PDE5 mechanism
- Acetylation may improve peptide stability versus standard PT-141
- Explored for libido support where vascular agents are insufficient
Potential Side Effects
- Nausea, sometimes pronounced
- Facial flushing and headache
- Transient increases in blood pressure
- Skin darkening or freckling with repeated melanocortin exposure
- Injection-site reactions
Common Dosing
For research use only and not medical advice: by analogy to bremelanotide and PT-141, research references describe roughly 0.5-2 mg per administration on an as-needed basis; this analog has no validated human dosing.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Uncontrolled hypertension or significant cardiovascular disease
- Pregnancy and breastfeeding
- Known hypersensitivity to melanocortin peptides
Oxytocin
Oxytocin is a nine-amino-acid hypothalamic neuropeptide hormone involved in social bonding, reproduction, and uterine contraction. It is FDA-approved clinically for labor induction and is studied for its effects on trust, intimacy, and social behavior.
Kisspeptin-10
A signaling peptide that sits at the top of the reproductive hormone axis, stimulating GnRH release. Studied for fertility, libido, and hormonal regulation.
- View
Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials
2019
- View
Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder
2019
- View
Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction
2004
- View
The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women
2022