N-Acetyl Epitalon Amidate
Also known as: N-Acetyl Epitalon Amidate, N-Acetyl Epithalon Amidate
A modified, more stable form of the tetrapeptide Epitalon studied for telomerase activation and pineal-mediated circadian and longevity effects.
Last updated
Mechanism of Action
N-Acetyl Epitalon Amidate is an N-terminally acetylated, C-terminally amidated analog of Epitalon (Ala-Glu-Asp-Gly), modifications intended to improve enzymatic stability and bioavailability. Like the parent peptide it is researched as an inducer of telomerase reverse transcriptase (TERT) expression, with reported elongation of telomeres in cultured cells. It is also proposed to act on the pineal gland to normalize melatonin secretion and circadian rhythm, and to influence gene expression linked to neuroendocrine aging.
- Half-life
- Short native peptide half-life; acetylation/amidation modestly extends stability
- Administration Routes
- subcutaneous, intranasal
- Research Status
- Research Chemical
Reported Benefits
- Studied for telomerase activation and telomere maintenance
- May support pineal regulation of melatonin and sleep cycles
- Investigated for antioxidant and neuroprotective effects
- Proposed anti-aging and longevity applications
- Greater peptide stability than unmodified Epitalon
Potential Side Effects
- Generally well tolerated in research settings
- Mild injection-site discomfort
- Possible transient headache or drowsiness
- Sparse long-term human safety data
Common Dosing
Research protocols reference subcutaneous doses of roughly 5-10 mg per cycle divided over consecutive days, often run in periodic cycles. For research use only; not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Known hypersensitivity to the peptide
- Pregnancy or breastfeeding
- Active malignancy, given theoretical telomerase concerns
Epitalon
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the pineal peptide epithalamin, studied for telomerase activation, circadian regulation, and longevity in animal and limited human research.
DSIP
Delta Sleep-Inducing Peptide is a small neuromodulatory nonapeptide studied for its effects on sleep architecture, stress hormones, and pain modulation.
Pinealon
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) studied in Russian research as a brain-targeted peptide bioregulator with proposed neuroprotective and cognition-supporting effects. It is part of the Khavinson short-peptide bioregulator family.
Humanin
Humanin is a mitochondrial-derived peptide studied for its cytoprotective, neuroprotective, and metabolic effects. The HNG (Humanin-G) analog is a more potent variant frequently used in research.
MOTS-c
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region that acts as a regulator of metabolism. It is studied for improving insulin sensitivity, metabolic flexibility, and exercise capacity.
- View
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
2003
- View
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
2025
- View
[AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.]
2020
- View
Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes
2007
- View
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
2025