What are mitochondrial-derived peptides?

They are small peptides encoded within mitochondrial DNA rather than the nuclear genome. MOTS-c and Humanin act as hormone-like signals regulating metabolism and cell survival.

Why combine MOTS-c and Humanin?

MOTS-c primarily drives AMPK-mediated metabolic regulation, while Humanin is mainly cytoprotective and anti-apoptotic, so the two are studied together for broader mitochondrial support.

Is this blend a proven longevity therapy?

No. Evidence is largely preclinical, and the blend is sold for research purposes without FDA approval.

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Longevity & Anti-aging

Preclinical

MOTS-c / Humanin Blend

Also known as: MOTS-C / Humanin Blend

A research blend of two mitochondrial-derived peptides, MOTS-c and Humanin, studied together for metabolic health, cytoprotection, and longevity. Both are encoded within mitochondrial DNA and act as signaling molecules.

Mechanism of Action

MOTS-c is encoded in the mitochondrial 12S rRNA region and activates the AMPK pathway, translocating to the nucleus under metabolic stress to regulate antioxidant and metabolic gene expression, thereby improving insulin sensitivity and fatty-acid oxidation. Humanin is encoded in the 16S rRNA region and is cytoprotective, binding the trimeric receptor (formyl peptide receptor-like 1 and the gp130/CNTFR/WSX-1 complex) to suppress apoptosis via Bax inhibition and to activate STAT3 survival signaling. Combining the two engages complementary metabolic-regulatory and anti-apoptotic mitochondrial pathways.

Half-life: Both peptides are short-lived in circulation (estimated minutes to a few hours); analog modifications can extend exposure.
Administration Routes: subcutaneous
Research Status: Preclinical