How does MGF differ from regular IGF-1?

MGF is the IGF-1Ec splice variant with a unique C-terminal E-domain. That E-domain has its own IGF-1-receptor-independent action focused on activating muscle stem cells, which standard mature IGF-1 does not replicate.

Why is MGF considered to act locally?

The unmodified peptide has a very short half-life and is rapidly cleared, so in research models its effects concentrate near the site of administration rather than acting systemically.

Is MGF approved for human use?

No. MGF is a research chemical with no regulatory approval, and any handling should be limited to laboratory research contexts.

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Muscle Growth

Research Chemical

MGF (Mechano Growth Factor)

Also known as: MGF, Mechano Growth Factor, Mechano-Growth Factor, MGF IGF-1 Ec, MGF IGF-1 EC, MGF C-Terminal, MGF (without PEG)

MGF is a splice variant of IGF-1 produced locally in muscle in response to mechanical loading or damage. It is studied for its role in activating muscle stem cells and supporting tissue repair.

Mechanism of Action

MGF is the IGF-1Ec splice variant generated by alternative splicing of the IGF-1 gene, characterized by a unique C-terminal E-domain peptide. This E-domain acts independently of the IGF-1 receptor to recruit and proliferate quiescent satellite (muscle stem) cells, delaying their differentiation so the pool available for repair expands. By upregulating myoblast proliferation and modulating local growth signaling, MGF is investigated for hypertrophy and regeneration following mechanical injury. Its action is highly localized and short-lived because the unmodified peptide is rapidly degraded in circulation.

Half-life: Very short, roughly 5-10 minutes for the unmodified peptide
Administration Routes: subcutaneous
Research Status: Research Chemical