How is Melanostatin DM different from tanning peptides like Melanotan?

It works in the opposite direction. Tanning peptides agonize MC1R to increase melanin, while Melanostatin DM antagonizes MC1R to reduce melanin and lighten the skin.

Is Melanostatin DM the same as Nonapeptide-1?

Melanostatin DM is a trade preparation centered on the Nonapeptide-1 active sequence, typically supplied in a cosmetic delivery base for topical use.

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Tanning & Skin

Collagen & Skin

Research Chemical

Melanostatin DM

Also known as: Melanostatin DM, Nonapeptide-1

Melanostatin DM is a topical nonapeptide marketed as a skin-brightening agent that reduces melanin production. It is studied for evening skin tone and lightening hyperpigmentation.

Mechanism of Action

Melanostatin DM is built around Nonapeptide-1, a sequence designed to antagonize the melanocortin-1 receptor (MC1R) on melanocytes. By competing with alpha-MSH at MC1R it suppresses downstream cAMP signaling and microphthalmia-associated transcription factor (MITF) activation, reducing transcription of tyrosinase and related melanogenic enzymes. The net effect is decreased melanin synthesis and a more even, lighter skin tone with continued topical use.

Half-life: Local topical action over hours; not systemically relevant
Administration Routes: topical
Research Status: Research Chemical