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Also known as: LL-37, Cathelicidin, Cathelicidin Antimicrobial Peptide
The only human cathelicidin antimicrobial peptide, central to innate immunity. Studied for antimicrobial, immunomodulatory, and wound-healing properties.
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LL-37 is the active fragment of the human cathelicidin hCAP18 and exerts direct antimicrobial activity by disrupting microbial membranes across bacteria, viruses, and fungi. Beyond killing pathogens, it acts as an immunomodulator, recruiting immune cells, neutralizing endotoxin, and promoting angiogenesis and re-epithelialization in wound healing. Its expression is partly vitamin D dependent, linking it to broader innate immune regulation.