Livagen
Also known as: Livagen
Livagen is a short synthetic peptide (Lys-Glu-Asp-Ala) developed in Russian peptide bioregulator research, studied for liver function and chromatin activation. It is positioned within the longevity and anti-aging space.
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Mechanism of Action
Livagen is a tetrapeptide bioregulator believed to act as an epigenetic modulator that binds AT-rich regions of DNA and promotes chromatin decondensation, restoring transcriptional activity in aging or senescent cells. In lymphocyte studies it reactivated heterochromatinized genes such as those on the inactive X chromosome and ribosomal gene clusters, increasing protein synthesis capacity. It is proposed as an organ-targeted bioregulator that normalizes hepatocyte and immune cell function during aging.
- Half-life
- Short, on the order of minutes for the unmodified tetrapeptide
- Administration Routes
- subcutaneous, intramuscular
- Research Status
- Research Chemical
Reported Benefits
- Studied for support of liver cell function
- May reactivate suppressed genes in senescent cells
- Investigated for immune and lymphocyte normalization
- Explored as a general anti-aging bioregulator
- May support protein synthesis in aged tissue models
Potential Side Effects
- Sparse human safety data
- Possible injection-site reactions
- Unknown long-term effects
- Effects largely characterized in cell-culture studies
Common Dosing
For research use only, not medical advice. Russian bioregulator literature references microgram-to-low-milligram courses given intermittently; exact research dosing varies and is not a personal-use recommendation.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy and breastfeeding
- Known peptide hypersensitivity
- Active malignancy without oversight
Pancragen
Pancragen is a synthetic short peptide bioregulator (Lys-Glu-Asp-Trp) studied in Russian research for supporting pancreatic function and glucose metabolism. It belongs to the Khavinson family of peptide bioregulators developed to normalize tissue-specific gene expression in aging organs.
Vesugen
Vesugen is a short tripeptide bioregulator studied for support of the vascular system and blood-vessel wall integrity. It is part of the Khavinson peptide family aimed at tissue-specific regulation.
N-Acetyl Epitalon Amidate
A modified, more stable form of the tetrapeptide Epitalon studied for telomerase activation and pineal-mediated circadian and longevity effects.
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Effects of Livagen peptide on chromatin activation in lymphocytes from old people
2002
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Effects of short peptides on lymphocyte chromatin in senile subjects
2004
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Anti-aging peptide bioregulators induce reactivation of chromatin
2006
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[The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function in norm and age-related pathology.]
2020