Kisspeptin-10
Also known as: Kisspeptin-10, KP-10, Metastin
A signaling peptide that sits at the top of the reproductive hormone axis, stimulating GnRH release. Studied for fertility, libido, and hormonal regulation.
Last updated
Mechanism of Action
Kisspeptin-10 is the shortest active fragment of kisspeptin and binds the KISS1R (GPR54) receptor on hypothalamic neurons to stimulate gonadotropin-releasing hormone (GnRH) secretion. This in turn drives LH and FSH release from the pituitary, regulating sex-steroid production and reproductive function. It acts as a master upstream regulator of the hypothalamic-pituitary-gonadal axis and also influences sexual and emotional brain processing.
- Half-life
- Short (minutes); rapidly cleared
- Administration Routes
- subcutaneous, intravenous
- Research Status
- Research Chemical
Reported Benefits
- Stimulates the natural reproductive hormone cascade (GnRH/LH/FSH)
- Studied for fertility and hypothalamic amenorrhea
- May enhance libido and sexual brain processing
- Acts upstream, preserving physiologic regulation
- Investigated as a fertility-treatment trigger
Potential Side Effects
- Generally well tolerated in clinical research
- Injection-site reactions
- Theoretical desensitization with continuous high dosing
- Limited long-term data
Common Dosing
Clinical research references vary widely from microgram bolus injections to infusions; standardized self-administration is not established. Educational reference only.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Hormone-sensitive cancers (theoretical)
- Pregnancy
- Not approved for human therapeutic use outside trials
- View
Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men
2011
- View
Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback
2012
- View
Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism
2013