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Also known as: Human Relaxin-2, Relaxin-2, Serelaxin
Human Relaxin-2 is a peptide hormone with vasodilatory and anti-fibrotic properties, also developed clinically as serelaxin. It is studied for cardiovascular and tissue-remodeling research.
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Relaxin-2 is a two-chain insulin-superfamily peptide that signals primarily through the RXFP1 G-protein-coupled receptor. Receptor activation raises cAMP and stimulates nitric-oxide and endothelin-pathway signaling, producing systemic vasodilation and increased arterial compliance. Relaxin-2 also downregulates pro-fibrotic TGF-beta signaling and activates matrix metalloproteinases, reducing collagen deposition and promoting tissue remodeling. These combined hemodynamic and anti-fibrotic actions drive its research interest in heart failure and fibrotic conditions.