Hexarelin
Also known as: Hexarelin, Examorelin, EP-23905
A potent growth hormone releasing peptide and ghrelin receptor agonist, among the strongest GH-stimulating GHRPs, with additional cardioprotective effects studied in preclinical work.
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Mechanism of Action
Hexarelin is a synthetic hexapeptide that strongly activates the GHS-R1a (ghrelin) receptor to drive substantial growth hormone release. It also binds the CD36 scavenger receptor, which underlies its researched cardioprotective and anti-fibrotic effects independent of GH. Its high potency can lead to faster receptor desensitization than gentler secretagogues, an important consideration in research design.
- Half-life
- Approximately 55-70 minutes
- Administration Routes
- subcutaneous
- Research Status
- Research Chemical
Reported Benefits
- Among the most potent GH-releasing peptides
- Cardioprotective effects in preclinical models (via CD36)
- Supports recovery and lean mass
- May have anti-fibrotic properties
- Effective at low microgram doses
Potential Side Effects
- Cortisol and prolactin elevation at higher doses
- Receptor desensitization with continuous use
- Water retention and tingling
- Increased appetite and flushing
Common Dosing
Research literature references ~100 mcg per dose, 1-2 times daily, with attention to desensitization over time. Educational reference only.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Active malignancy
- Uncontrolled diabetes
- Cardiovascular instability (consult research literature)
- Pregnancy or breastfeeding
CJC-1295
A long-acting growth hormone releasing hormone (GHRH) analog that stimulates the pituitary to produce more growth hormone. Often paired with a ghrelin mimetic for synergistic GH release.
Sermorelin
A GHRH analog comprising the first 29 amino acids of growth hormone releasing hormone, historically used to assess and stimulate pituitary GH output. A gentler, physiologic GH peptide.
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Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man
1994
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Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone
2001
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Growth hormone-independent cardioprotective effects of hexarelin in the rat
1999
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CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart
2002