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Also known as: Gut Inflammation Blend, Gastro Inflammation Research Formula, Gastro Inflammation Blend (BPC-157, KPV, N-Acetyl Larazotide)
A multi-component research blend combining the cytoprotective peptide BPC-157 with the anti-inflammatory tripeptide KPV plus fatty-acid mediators aimed at gastrointestinal mucosal repair. It is studied for its combined effects on gut-barrier integrity and local inflammation.
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BPC-157 upregulates angiogenic and growth-factor signaling (VEGFR2, the nitric oxide system, and the EGR-1/FAK pathways) to accelerate epithelial and vascular repair. KPV, the C-terminal tripeptide of alpha-MSH, suppresses NF-kB and pro-inflammatory cytokine transcription and is transported across enterocytes via the PepT1 transporter. Palmitoylethanolamide (PEA) acts on PPAR-alpha and indirectly on cannabinoid-related receptors to dampen mast-cell and microglial inflammation, while tributyrin delivers butyrate as a histone-deacetylase inhibitor and energy substrate for colonocytes. The combination targets barrier integrity and mucosal inflammation through complementary pathways.