Ghrelin Acetate
Also known as: Ghrelin Acetate, Ghrelin
Ghrelin Acetate is the acetate salt of ghrelin, the endogenous gut-derived hormone that drives hunger and stimulates growth hormone release. It is studied for appetite and GH-axis research.
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Mechanism of Action
Ghrelin is a 28-amino-acid peptide that, in its acylated form, binds the growth hormone secretagogue receptor (GHS-R1a) in the hypothalamus and pituitary. Receptor activation stimulates phospholipase C signaling, raising intracellular calcium and driving robust pulsatile growth hormone secretion. Centrally, ghrelin activates NPY/AgRP neurons in the arcuate nucleus to increase appetite and promote energy storage. It also influences gastric motility and reward pathways, making it a central regulator of energy homeostasis.
- Half-life
- Approximately 10-30 minutes for acylated ghrelin
- Administration Routes
- subcutaneous
- Research Status
- Research Chemical
Reported Benefits
- Potently stimulates growth hormone release
- Increases appetite in research models of cachexia and low intake
- Promotes gastric motility
- Used as a reference ligand for GHS-R pharmacology
- Investigated for metabolic and energy-balance research
Potential Side Effects
- Marked increase in hunger
- Transient changes in cortisol and prolactin
- Possible water retention
- Short-lived effects requiring frequent dosing
Common Dosing
Research studies have used microgram-per-kilogram intravenous or subcutaneous doses to probe GH and appetite responses. Provided as research-use information only and not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Not for human therapeutic use
- Avoid in active malignancy due to GH/IGF-1 stimulation
- Caution where increased appetite is undesirable
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