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Also known as: GHK-Cu, Copper Peptide, Copper Tripeptide-1
A naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) widely researched for skin regeneration, collagen synthesis, and wound healing. Common in topical cosmetics.
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GHK-Cu is a tripeptide that binds copper(II) ions with high affinity and modulates the expression of numerous genes involved in tissue remodeling. It stimulates collagen, elastin, and glycosaminoglycan synthesis by fibroblasts, promotes angiogenesis, and acts as an antioxidant and anti-inflammatory agent. Declining GHK levels with age are associated with reduced regenerative capacity, which underlies its use in skin and wound research.