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Also known as: FGL, FGL-S
FGL is a synthetic peptide derived from the neural cell adhesion molecule (NCAM) studied as a cognitive enhancer and neuroprotective agent.
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FGL is a short peptide mimetic of the second fibronectin type III module of NCAM that binds and activates the fibroblast growth factor receptor 1 (FGFR1). FGFR1 activation triggers downstream signaling that promotes neurite outgrowth, synaptic plasticity, and long-term potentiation in the hippocampus. It also exerts anti-inflammatory and neuroprotective effects by modulating microglial activation and reducing neuronal apoptosis in injury and aging models.