FGL (FGL-S)
Also known as: FGL, FGL-S
FGL is a synthetic peptide derived from the neural cell adhesion molecule (NCAM) studied as a cognitive enhancer and neuroprotective agent.
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Mechanism of Action
FGL is a short peptide mimetic of the second fibronectin type III module of NCAM that binds and activates the fibroblast growth factor receptor 1 (FGFR1). FGFR1 activation triggers downstream signaling that promotes neurite outgrowth, synaptic plasticity, and long-term potentiation in the hippocampus. It also exerts anti-inflammatory and neuroprotective effects by modulating microglial activation and reducing neuronal apoptosis in injury and aging models.
- Half-life
- Short peptide half-life; rapidly cleared from plasma
- Administration Routes
- subcutaneous, intranasal
- Research Status
- Preclinical
Reported Benefits
- Promotes synaptic plasticity and long-term potentiation
- Studied for memory and learning enhancement
- Neuroprotective in injury and neurodegeneration models
- Anti-inflammatory effects on neural tissue
- Investigated for cognitive recovery after stress or injury
Potential Side Effects
- Limited human data; safety not well established
- Possible injection-site reaction
- Theoretical effects on cell proliferation via FGFR signaling
- Unknown long-term effects
Common Dosing
Animal research has used parenteral microgram-to-milligram-per-kilogram doses; no validated human regimen exists. For research use only; not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Known hypersensitivity to the peptide
- Active or history of malignancy, given FGFR pathway activation
- Pregnancy or breastfeeding
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A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation
2004
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An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons
2004
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Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement
2012
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The neural cell adhesion molecule-derived peptide FGL facilitates long-term plasticity in the dentate gyrus in vivo
2011
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A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo
2005