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Also known as: DNSP-11
DNSP-11 is an 11-amino-acid peptide derived from the proGDNF (glial cell line-derived neurotrophic factor) precursor that is being studied for its neuroprotective and neurorestorative effects on dopaminergic neurons.
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DNSP-11 is a dopamine neuron stimulating peptide cleaved from the pro-region of proGDNF, distinct from mature GDNF and acting independently of the canonical RET/GFRalpha-1 receptor complex. In preclinical models it promotes survival of dopaminergic neurons, increases dopamine synthesis and turnover, and reduces apoptosis through modulation of intracellular signaling and resistance to oxidative and excitotoxic stress. It has been shown to elevate striatal dopamine metabolites and improve behavioral measures in lesioned rodent models of Parkinson-like dopaminergic loss.