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Also known as: Cortexin
Cortexin is a polypeptide complex extracted from cerebral cortex tissue, used clinically in Russia and several other countries as a neuroprotective and nootropic agent. In Western markets it is sold as a research chemical. (Cortexin is a registered polypeptide drug in some countries; presented here for educational/research reference only, not as medical guidance.)
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Cortexin is a low-molecular-weight mixture of neuropeptides and amino acids derived from bovine or porcine cerebral cortex. It is proposed to exert tissue-specific neurotrophic and neuroprotective effects by modulating the balance of excitatory and inhibitory amino acids, reducing glutamate excitotoxicity, and lowering oxidative stress and free-radical damage in neurons. Experimental and clinical reports also describe upregulation of neurotrophic factors and improved bioelectrical activity of the brain, supporting its use in ischemic, traumatic, and cognitive disorders.