Cortagen
Also known as: Cortagen
Cortagen is a short synthetic peptide (Ala-Glu-Asp-Pro) studied as a bioregulator for the brain and nervous tissue. It is part of the Khavinson family of short peptide bioregulators.
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Mechanism of Action
Cortagen is a tetrapeptide (AEDP) proposed to act as a neuro-specific bioregulator by entering cells, interacting with DNA, and modulating expression of genes in cortical neurons and peripheral nerve tissue. It is reported to support neuronal differentiation, promote neurite outgrowth, and influence neurotrophic and antioxidant gene programs. By normalizing protein synthesis in nervous tissue, it is studied for supporting cognitive function and nerve regeneration.
- Half-life
- Short (minutes), typical of small tetrapeptides cleared rapidly from circulation
- Administration Routes
- subcutaneous, intramuscular
- Research Status
- Research Chemical
Reported Benefits
- Studied for support of brain and peripheral nerve tissue
- May promote neurite outgrowth and neuronal differentiation
- Proposed to support cognitive function and recovery
- Investigated for neuroprotective and antioxidant effects
- Short peptide with generally low immunogenicity
Potential Side Effects
- Limited human safety data
- Possible injection-site irritation
- Potential hypersensitivity reactions
- Unverified long-term neurological effects
Common Dosing
For research use only and not medical advice: bioregulator references describe roughly 100-200 mcg daily subcutaneously or intramuscularly over 10-20 day courses; no established clinical dosing exists.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy and breastfeeding
- Known peptide hypersensitivity
- Acute neurological illness without medical oversight
Cortexin
Cortexin is a polypeptide complex extracted from cerebral cortex tissue, used clinically in Russia and several other countries as a neuroprotective and nootropic agent. In Western markets it is sold as a research chemical. (Cortexin is a registered polypeptide drug in some countries; presented here for educational/research reference only, not as medical guidance.)
Pinealon
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) studied in Russian research as a brain-targeted peptide bioregulator with proposed neuroprotective and cognition-supporting effects. It is part of the Khavinson short-peptide bioregulator family.
N-Acetyl Semax Amidate
N-Acetyl Semax Amidate is a stabilized analog of the ACTH(4-10)-derived nootropic peptide Semax, modified for durability and intranasal use. It is studied for cognition, focus, and neuroprotection.
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Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray
2004
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Effect of tetrapeptide cortagen on regeneration of sciatic nerve
2000
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The delayed effect of cortagen on the restoration of injured nerve function
2002
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[Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia]
2011