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Also known as: Colivelin
Colivelin is a synthetic hybrid neuroprotective peptide that fuses activity-dependent neurotrophic factor (ADNF) with a potent Humanin derivative, studied for protecting neurons against amyloid-beta and other neurotoxic insults.
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Colivelin is a fusion of the ADNF-derived peptide and a stabilized Humanin analog (AGA-(C8R)-HNG17), combining two neuroprotective modules into one molecule. It activates pro-survival signaling, notably the STAT3 pathway, and engages Humanin-associated receptor systems to suppress neuronal apoptosis induced by amyloid-beta, mutant familial Alzheimer genes, and prion fragments. By upregulating anti-apoptotic signaling at femtomolar to picomolar concentrations, it protects cholinergic and other neurons and has shown memory-preserving effects in rodent models.