BPC-157
Also known as: BPC-157, Body Protection Compound-157
A synthetic peptide fragment derived from a protein found in gastric juice, studied for its broad tissue-healing and cytoprotective effects. Popular in research for tendon, ligament, muscle, and gut repair.
Last updated
Mechanism of Action
BPC-157 is thought to upregulate angiogenesis by promoting VEGFR2 expression and activating the VEGFR2-Akt-eNOS signaling pathway, increasing blood vessel formation at injury sites. It modulates growth-hormone receptor expression in tendon fibroblasts and appears to influence the nitric oxide system. Animal studies also describe protective effects on the gut-brain axis and dopaminergic, serotonergic, and GABAergic systems.
- Half-life
- Approximately 4-6 hours (estimated; rapidly cleared)
- Administration Routes
- subcutaneous, intramuscular, oral
- Research Status
- Research Chemical
Reported Benefits
- Accelerated tendon, ligament, and muscle healing in animal models
- Cytoprotective and ulcer-healing effects on the GI tract
- Promotes angiogenesis (new blood vessel formation) at injury sites
- May reduce inflammation in soft tissue and joints
- Reported neuroprotective effects in preclinical research
- Anecdotal support for faster recovery from overuse injuries
Potential Side Effects
- Generally well tolerated in animal studies with low toxicity
- Possible injection-site irritation, redness, or bruising
- Occasional reports of mild nausea or fatigue (anecdotal)
- Long-term human safety data is lacking
Common Dosing
Research literature commonly references 200-500 mcg per administration, once or twice daily, in animal-equivalent and anecdotal human protocols. Not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Known or active malignancy (theoretical concern due to angiogenic activity)
- Pregnancy or breastfeeding (no safety data)
- Not approved for human use; sold as research chemical only
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Stable Gastric Pentadecapeptide BPC 157 and Wound Healing
2021
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The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
2011
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Pentadecapeptide BPC 157 and the central nervous system
2022
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Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review
2025