BAM-15
Also known as: BAM-15
A small-molecule mitochondrial protonophore (uncoupler) studied as a metabolic compound for fat loss and metabolic health. It is not a peptide but is commonly sold alongside research peptides.
Last updated
Mechanism of Action
BAM-15 is a mitochondrial uncoupler that dissipates the proton gradient across the inner mitochondrial membrane, partially decoupling electron transport from ATP synthesis. This increases substrate oxidation and energy expenditure as heat rather than ATP. Unlike the older uncoupler DNP, BAM-15 is reported to have a wider safety window and does not depolarize the plasma membrane at effective concentrations. In rodent studies it reduced adiposity and improved insulin sensitivity without raising body temperature in the way DNP does.
- Half-life
- Several hours in rodent pharmacokinetic studies
- Administration Routes
- oral, subcutaneous
- Research Status
- Preclinical
Reported Benefits
- Increases mitochondrial energy expenditure
- Studied for fat loss in animal models
- Reported improvements in insulin sensitivity
- Wider safety margin than the classic uncoupler DNP in preclinical work
- Investigated for protection against metabolic and oxidative stress
Potential Side Effects
- Potential overheating or hyperthermia inherent to uncouplers
- Fatigue or reduced exercise capacity
- Possible gastrointestinal upset
- Unknown long-term safety in humans
Common Dosing
Dosing is defined only in animal research, typically expressed as mg per kg body weight; no validated human dosing exists. Provided for research-use-only context and not as personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- No established human safety profile
- Cardiovascular or thermoregulatory disorders
- Pregnancy and breastfeeding
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Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane
2014
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Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice
2020
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Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice
2024
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BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases
2023