Why is AHK bound to copper?

The copper ion serves as an enzymatic cofactor and stabilizes the peptide's signaling activity, which is central to its reported hair and skin benefits.

Can AHK-Cu stain skin or fabric?

Copper peptide complexes have a characteristic blue color and can leave a temporary tint, so formulations are usually low-concentration and rinse or absorb cleanly.

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Collagen & Skin

Research Chemical

AHK-Cu

Also known as: AHK-Cu, AHK Copper

AHK-Cu is the copper-bound form of the Ala-His-Lys tripeptide, used cosmetically to support hair follicles and dermal renewal.

Mechanism of Action

AHK-Cu is the copper(II) complex of Tripeptide-3, in which the histidine and terminal amine coordinate a copper ion to form a stable signaling complex. The bound copper acts as a cofactor for enzymes such as lysyl oxidase and superoxide dismutase, and the complex is reported to stimulate dermal papilla cells and VEGF-driven angiogenesis around hair follicles. This combination of trace-metal delivery and growth-factor signaling is studied for promoting the anagen phase and supporting collagen and elastin remodeling.

Half-life: Topical; acts locally with negligible systemic exposure
Administration Routes: topical
Research Status: Research Chemical