What is the difference between AHK and AHK-Cu?

AHK is the free tripeptide, while AHK-Cu is the same peptide pre-bound to a copper ion, which is the form most often used for its copper-dependent signaling effects.

Is AHK related to GHK?

Both are short copper-affinity tripeptides used in cosmetics; AHK is most associated with hair-related research while GHK is best known for skin remodeling.

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Collagen & Skin

Research Chemical

AHK (Tripeptide-3)

Also known as: AHK, Tripeptide-3

AHK is a copper-affinity tripeptide (Ala-His-Lys) studied as a cosmetic signaling peptide for hair and skin support.

Mechanism of Action

AHK (Alanine-Histidine-Lysine, Tripeptide-3) is a histidine-containing tripeptide that can chelate copper ions and act as a signaling peptide at the dermal level. It is reported to stimulate dermal papilla fibroblasts and upregulate vascular endothelial growth factor (VEGF), promoting microvascular support around the hair follicle. By improving the follicular microenvironment and matrix protein synthesis, it is studied for extending the anagen growth phase and supporting collagen remodeling in skin.

Half-life: Topical; acts locally with negligible systemic exposure
Administration Routes: topical
Research Status: Research Chemical