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Also known as: Adipotide, FTPP
Adipotide is an experimental peptidomimetic studied in animals for targeted destruction of the blood supply feeding white fat tissue.
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Adipotide (also called FTPP or prohibitin-targeting peptide-1) is a fusion of a CKGGRAKDC homing sequence that binds prohibitin on the surface of white adipose vasculature, linked to a KLAKLAK pro-apoptotic sequence. The homing peptide directs the construct selectively to endothelial cells of fat-supplying capillaries, where the membrane-disrupting KLAKLAK domain triggers mitochondrial apoptosis. Loss of this vasculature starves white adipose tissue, leading to fat resorption and weight loss in preclinical models.