Loading peptide…
PeptideChat is for educational and research purposes only. Nothing on this site constitutes medical advice. Peptides are sold as research chemicals only and are not intended for human use. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. PeptideChat is an independent educational resource — not a pharmacy, compounding, or 503A/503B outsourcing facility — and does not sell products or provide medical advice.
Also known as: A4 Amyloid Beta, Amyloid Beta
A4 Amyloid Beta refers to the amyloid-beta peptide derived from the amyloid precursor protein and central to Alzheimer's disease research. It is used purely as a research reagent for neurodegeneration studies. This is a neurotoxic laboratory reagent intended strictly for in-vitro research; it is not for administration.
Sign in to rate this peptide.
Amyloid-beta is generated by sequential beta- and gamma-secretase cleavage of the amyloid precursor protein (APP), producing peptides such as Abeta40 and the more aggregation-prone Abeta42. These monomers self-assemble into soluble oligomers and insoluble fibrils that deposit as the amyloid plaques characteristic of Alzheimer's pathology. Oligomeric amyloid-beta is implicated in synaptic dysfunction, oxidative stress, and neuroinflammation. As a research reagent, it is used to model aggregation kinetics and amyloid toxicity in vitro and in animal systems.