Is 5-Amino-1MQ a peptide?

No. It is a small-molecule methylquinolinium compound that inhibits the NNMT enzyme, but it is commonly sold alongside research peptides for metabolic research.

What does NNMT inhibition do?

Inhibiting NNMT spares nicotinamide and SAM, which can raise NAD+ and methylation substrate availability and, in animal studies, shift fat cells away from storage.

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Weight & Metabolic

Longevity & Anti-aging

Preclinical

5-Amino-1MQ

Also known as: 5-Amino-1MQ

5-Amino-1MQ is a small-molecule inhibitor of the enzyme NNMT, studied in animal models for its potential to reduce fat storage and support metabolic health.

Mechanism of Action

5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme over-expressed in adipose tissue that consumes methyl groups and NAD precursors. By inhibiting NNMT, it raises intracellular nicotinamide and S-adenosylmethionine (SAM) levels, which can increase cellular NAD+ and SAM availability. Higher NAD+ supports sirtuin activity and oxidative metabolism in adipocytes, and in rodent studies this shifts white adipocytes toward increased lipolysis and energy expenditure rather than lipid storage.

Half-life: Approximately 4-8 hours (estimated from preclinical data)
Administration Routes: oral
Research Status: Preclinical