5-Amino-1MQ
Also known as: 5-Amino-1MQ
5-Amino-1MQ is a small-molecule inhibitor of the enzyme NNMT, studied in animal models for its potential to reduce fat storage and support metabolic health.
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Mechanism of Action
5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme over-expressed in adipose tissue that consumes methyl groups and NAD precursors. By inhibiting NNMT, it raises intracellular nicotinamide and S-adenosylmethionine (SAM) levels, which can increase cellular NAD+ and SAM availability. Higher NAD+ supports sirtuin activity and oxidative metabolism in adipocytes, and in rodent studies this shifts white adipocytes toward increased lipolysis and energy expenditure rather than lipid storage.
- Half-life
- Approximately 4-8 hours (estimated from preclinical data)
- Administration Routes
- oral
- Research Status
- Preclinical
Reported Benefits
- May reduce white adipose tissue fat storage in animal models
- Associated with increased cellular NAD+ and SAM levels
- Studied for improved insulin sensitivity and glucose handling
- May support increased energy expenditure in adipocytes
- Investigated for preserving or supporting lean muscle mass
- Orally bioavailable small molecule in research settings
Potential Side Effects
- Limited human safety data; long-term effects unknown
- Possible gastrointestinal upset
- Theoretical disruption of methylation balance
- Headache or fatigue reported anecdotally
Common Dosing
For research use only: protocols in the literature and anecdotal sources reference oral doses of roughly 50-150 mg once daily. Not personal medical advice.
The dosing information above is aggregated from research literature and anecdotal community reports for educational purposes only. It is not a recommendation, prescription, or medical advice. Peptides are sold as research chemicals only and are not intended for human use.
Contraindications
- Pregnancy and breastfeeding
- Unknown safety in individuals with hepatic or renal impairment
- Concurrent use with other methylation-modulating agents without oversight
NAD+
NAD+ is an essential coenzyme central to cellular energy production and DNA repair whose levels decline with age. It is studied and supplemented for longevity, mitochondrial function, and metabolic health. Note: NAD+ is a coenzyme, not a peptide, commonly sold alongside longevity research compounds.
NMN
NMN is a direct biosynthetic precursor of NAD+ used to raise cellular NAD+ levels. It is studied for longevity, metabolic health, and mitochondrial function. Note: NMN is a small-molecule NAD+ precursor, not a peptide, but is catalogued with longevity research compounds.
MOTS-c
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region that acts as a regulator of metabolism. It is studied for improving insulin sensitivity, metabolic flexibility, and exercise capacity.
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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
2014
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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
2018
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Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome
2024
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Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes
2021